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                張靈玲

                  發布beat365手机版官方网站: 2019-12-16   信息員:


                博士、教授、博士⊙生導師

                福建農∞林大學生物技術系

                電話:0591-83789258

                電子信箱:lingling00264@163.com


                中華預防醫學會媒介生物學及控制分會蚊蟲Ψ 學組委員,中國生物化學與分子生物學學會他大可在与吴端刚j手之际对他实行脑b攻击農業生物化學與分子生物學分會理事。福建省“五四青年獎章”獲得者,入選福建省高校傑出青年】科研人才計劃、福建省新世紀人才及福建農林大學拔尖人才,獲得2019年福建省“向上向善育人工程基金”獎教金及福建農林大學第二屆“嚴家顯最高这也是考虑到出行獎教金”和第一屆“教學名師”。2013.8-2014.8美國密蘇裏大學訪問學者。1999年起從事殺蟲微生物資源篩選、殺蟲機理及應用ζ 研究。主持國啧啧朱俊州神经兮兮家自然科學青年基金、教育部博士确就是这性格點青年基金、福建省高校傑出青年科研人才計劃等課題。以第1發明人獲得授權國家發明◥專利7項,國際專利1項。以第1/通訊作○者發表SCI收錄論文24篇。是國際期刊《Parasite Vector》、《Scientific Reports》等論文審稿人。獨立指導的本科生連續四屆(第十二至十■五屆)獲得全國大學给我狠狠揍他生“挑戰杯”競賽一/二等獎及福建省大學生“挑戰杯”競賽特/一等獎。培養的學生多人次獲得國家獎學金、嚴家顯獎≡學金、校“三好生”等榮譽。目前工作重心主要開展第三方蛋★白對▆Bt毒素殺蟲調控及Bt抗紫外機好张建东气急败坏理研究



                發表文章(第1/通訊作者)

                 Xiaohua Hu, Hong Chen, Jin Xu, Guohui Zhao, Xianhui Huang, Jiannan Liu, Khadija Batool, Chenxu Wu, Songqing Wu, Enjiong Huang, Juan Wu, Munmun Chowhury, Jie Zhang, Xiong Guan, Xiaoqiang Yu, Lingling Zhang. Function of Aedes aegypti galectin-6 in modulation of Cry11Aa toxicity. Psticide Biochemistry and Physiology. 2020, 162, 96-104

                 Khadija Batool, Intikhab Alam, Liang Jin, Jin Xu, Chenxu Wu, Junxiang Wang, Enjiong Huang, Xiong Guan, Xiaoqiang Yu and Lingling Zhang. CTLGA9 interacts with ALP1 and APN receptors to modulate Cry11Aa toxicity in Aedes aegypti. j. Agric. Food Chem. 2019. Doi:10.1021/acs.jafc.9b01840

                 Guo-hui Zhao ,Jian-nan Liu , Xiao-hua Hu, Khadija Batool, Liang Jin, Cheng-xu Wu, Juan Wu, Hong Chen, Xiao-yan Jiang, Zhao-hui Yang, Xian-hui Huang, En-jiong Huang, Xiao-Qiang Yu, Xiong Guan and Ling-ling Zhang. Cloning, expression and activity of ATP-binding protein in Bacillus thuringiensis toxicity modulation against Aedes aegypti. Parasites & Vectors, 2019, 2:319

                Lingling Zhang(#), Xiaohua Hu, Songqing Wu, Kahdija Batool, Munmun Chowdhury, Yi Lin, Zhang J, Sarjeet S. Gill, Xiong Guan (*) and Xiaoqiang Yu (*). 2018. Aedes aegypti Galectin competes with Cry11Aa for binding to ALP1 to modulate Cry toxicity, Journal of Agricultural and Food Chemistry, 66(51):13435-13443

                Lingling Zhang(#), Xiaojuan Zhang, Khadija Batool, Xiaohua Hu, Mingfeng Chen, Jin Xu, Junxiang Wang, Xiaohong Pan, Tianpei Huang, Lei Xu, Xiaoqiang Yu(*) and Xiong Guan(*). 2018. Comparison and mechanism of the UV-resistant mosquitocidal Bt mutant LLP29-M19, Journal of Medical Entomology, 551):210-216

                Khadija Batool, Intikhab Alam, Guohui Zhao, Junxiang Wang, Jin Xu, Xiaoqiang Yu, Enjiong Huang, Xiong Guan and Lingling Zhang. 2018. C-type Lectin-20 interacts with ALP1 receptor to reduce Cry toxicity in Aedes aegypti. Toxins. 10: 390

                Khadija Batool, Intikhab Alam, Songqing Wu, Wencheng Liu, Guohui Zhao,Mingfeng Chen, Junxiang Wang, Jin Xu, Tianpei Huang, Xiaohong Pan, Xiaoqiang Yu, Xiong Guan, Lei Xu & Lingling Zhang(*). 2018. Transcriptomic Analysis ofAedes aegypti in Response toMosquitocidal Bacillus thuringiensisLLP29 Toxin. Scientific Reports, 8:12650

                Lingling Zhang(#), Guohui Zhao, Xiaohua Hu, Jiannan Liu, Mingwei Li, Kahdija Batool, Mingfeng Chen, Junxiang Wang, Jin Xu, Tianpei Huang, Xiaohong Pan, Lei Xu, Xiaoqiang Yu(*) and Xiong Guan(*),Cry11Aa interacts with the ATP-Binding protein from Culex quinquefasciatus to improve the toxicity, Journal of Agricultural and Food Chemistry, 2017, 65:10884-10890

                Ensi Shao, Guifang Lin, Sijun Liu(*), Xiaoli Ma, Ming-feng Chen, Li Lin, Sonqing Wu, Li Sha, Zhaoxia Liu, Xiaohua Hu, Xiong Guan, Lingling Zhang(*). 2017. Identification of transcripts involved in digestion, detoxification and immune response from transcriptome of Empoasca vitis ( Hemiptera: Cicadellidae) nymphs. Genomics, 1091):58-66

                Qiuqiu Lin, Pengli Zhu, Rebeca Carballar-Lejarazu, Ivan Gelbic, Xiong Guan, Lei Xu(*), Lingling Zhang(*). 2017. The colonization of Bacillus thuringiensis strains in bryophytes. Turkish Journal of Biology, 41: 41-48

                Xiaohua Hu, Yajie Guo, Songqing Wu, Zhaoxia Liu, Tao Fu, Ensi Shao, Carballar-Lejarazú Rebeca, Guohui Zhao, Zhipeng Huang, Ivan Gelbi?, Xiong Guan, Shuangquan Zou, Lei Xu(*), and Lingling Zhang(*). 2017. Effect of proteolytic and detoxification enzyme inhibitors on Bacillus thuringiensis var. israelensis tolerance in the mosquito Aedes aegypti. Biocontrol Science & Technology, 272):169-179

                Lingling Zhang (#), Xiaojuan Zhang, Yi Zhang, Songqin Wu, Ivan Gelbic, Lei Xu, Xiong Guan(*). 2016. A new formulation of Bacillus thuringiensis: UV protection and sustained release mosquito larvae studies, scientific report, 6: 39425

                Songqing Wu, Yan Peng, Zhangmin Huang, Zhipeng Huang, Lei Xu, Ivan Gelbi?, Xiong Guan, Lingling Zhang(*), and Shuangquan Zou (*). 2016. Isolation and characterization of a novel native Bacillus thuringiensis strain BRC-HZM2 capable of degrading chlorpyrifos, Journal of Basic Microbiology, 26: 227-238

                Songqing Wu, Wei Wu, Xiaoli Zhu, Zhaoxia Liu, Carballar-Lejarazú Rebeca,Tao Fu, Chaoqiang Han, Ensi Shao, Xiaohong Pan, Zhipeng Huang, Lei Xu,Shuangquan Zou, Lingling Zhang(*) & Xiong Guan(*). 2016. Physiological and biochemical response of Aedesaegypti tolerance to Bacillus thuringiensis. Biocontrol Science and Technology, 26: 227-238

                Lingling Zhang (#), Jie Yu, Yufei Xie, Hongli Lin, Zhipeng Huang, Lei Xu, Ivan Gelbi? and Xiong Guan (*), Biological activity of Bacillus thuringiensis chitinase against Caenorhabditis elegans. Journal of Economic Entomology, 2014, 1072):551-558

                Songqing Wu, Yanjiao Lan, Dongmei Huang, Yan Peng, Zhipeng Huang, Lei Xu, Ivan, Gelbi? Rebeca Carballar-Lejarazu, Xiong Guan, Lingling Zhang (*), and Shuangquan Zou(*), Use of spent mushroom substrate for production of Bacillus thuringiensis by solid-state fermentation, J Econ Entomol.2014, 1071):137-143

                Lingling Zhang(#),Baozhen Tang, Eenjiong Huang, Zhipeng Huang, Zhaoxia Liu, Tianpei Huang, Ivan Gelbi? and Xiong Guan (*), Different toxicity of the novel Bacillus thuringiensis strain LLP29 against Aedes albopictus and Culex quinquefasciatus, J Econ Entomol., 2013, 160 (2): 1098-1102

                Lingling Zhang(#), Sixin Qiu, Tianpei Huang, Zhipeng Huang, Lei Xu, Changbiao Wu, Ivan Gelbi? and Xiong Guan(*), Effect of chemical additives on Bacillus thuringiensis against Plutella xylostella, J Econ Entomol, 2013, 160 (3): 1075-1080

                Songqing Wu, Yanjiao Lan, Zhimao Wu, Yan Peng, Siqi Chen, Zhipeng Huang, Lei Xu, Ivan Gelbi?, Xiong Guan, Lingling Zhang(*) and Shuangquan Zou(*), Pretreatment of spent mushroom substrate for enhancing the conversion of fermentable sugar, Bioresource Technology, 2013, 148: 596-600

                Changbiao Wu, Lili Wu, Lei Xu, Lingling Zhang (*) andXiong Guan, Parasporal crystal proteins of Bacillus thuringiensis strain BT6, originated from the faecal of Sika Deer, demonstrates anticoccidial activity against Eimeria tenella, African Journal of Microbiology Research, 2013, 7(33)4261-4264

                Lingling Zhang(#), Qi Zhang, Enjiong Huang, Mingwei Li, Tianpei Huang, Changbiao Wu, Xiong Guan(*) and Ivan Gelbi?(*), A differentially displayed mRNA relates to the resistance of Aedes albopictus selected in vitro-activated Cyt1Aa6, Journal of the America Mosquito Control Association2012, 28: 327-329

                Lingling Zhang(#), Yan Peng, Songqing Wu, Linying Sun, Enjiong Huang, Tianpei Huang, Lei Xu, Changbiao Wu, Ivan Gelbi? and Xiong Guan(*), Microbial Ecology and Association of Bacillus thuringiensis in Chicken feces Originating from feed, Current Microbiology, 2012, 65: 784-791

                Lingling Zhang(#), Sixin Qiu, Tianpei Huang, Zhipeng Huang, Lei Xu, Changbiao Wu, Ivan Gelbi? and Xiong Guan(*), Effect of chemical additives on Bacillus thuringiensis against Plutella xylostella, J Econ Entomol, 2013, 160 (3): 1075-1080

                Lingling Zhang(#), Songqing Wu, Yan Peng, Mingwei Li, Linying Sun, Eenjiong Huang, Xiong Guan and Ivan Gelbic(*), The novel mosquitocidal Bacillus thuringiensis strain LLP29 provides potential for use in practice, Journal of Vector Ecology, 2011, 36(2): 458-460

                Lingling Zhang(#), Enjiong Huang, Jin Lin, Ivan Gelbic*, Qunlin Zhang, Yi Guan, Tianpei Huang and Xiong Guan (*), A novel mosquitocidal Bacillus thuringiensis strain LLP29 isolated from the Phylloplane of Magnolia denudata, Microbiological Research, 2010, 16133-141

                Zhang L(#), Huang E, Gelbi? I,  Guan C, Guan Y and Guan X. Cloning, expression and characterisation of a promising mosquitocidal gene. Indian Journal of Experimental Biology, 2009, 47: 799-803

                Zhang L(#), Lin J, Luo L, Guan C, Zhang Q, Guan Y and Guan X. A novel Bacillus thuringiensis strain LLB6 isolated from bryophyte and its new cry2Ac-type gene. Letters in Applied Microbiology, 2007, 44: 301-307


                授權國家發明專利

                A張靈玲、陳宇熹、關雄、黃天培、葉舒婷、林誌藝、蔡美鳳、鄭毅、吳麗雲、吳松青、翁林捷、沙莉, 殺蚊蘇雲金芽孢桿菌液體培養基, 2012.4.18,  中國,ZL201010200543.X

                B張靈玲、吳松青、彭艷、關雄、張小娟、黃冬梅、陳忍、姚祖傑、張小娟,一種蘇雲金桿很显然自己是遭到别人菌液態發酵培養基的制備方法,2012.12.19,中國,ZL201110258526.6

                C張靈玲、吳松青、彭艷、關雄、黃冬梅、蘭艷嬌、洪冬華,一種蘇雲金桿菌固態發酵培養基的制備方法,2013.5.15,中國,ZL 201110207054.1

                D張靈玲、許雷、關雄、張永嶸,一種蘇雲金芽胞桿菌乳化發酵培養基,2013.6.19,中國,ZL 201210278484.7

                E張靈玲、許雷、關雄、張永嶸,一種蘇雲金№芽胞桿菌糖苷發酵培養基,2013.10.23,中國,CN201210278035.2

                F張靈玲、邵恩斯、關雄、劉斯軍、莊浩瀚、徐碧虹、林莉、林立金,對水稻褐飛虱高毒力的Bt毒素Cry1Ab-loop2-P2S和工程菌,2014.5. 21,中國,201210433476.5

                H張靈玲,關雄,張小娟,顧曉軍,張意,鄭曉娟,吳松青,王官棟,吳誌卯,劉紅,一種殺滅蚊∩子幼蟲的蘇雲金桿菌制劑及卐其制備方法,2015.11.18,中國,ZL201310733631.X

                I關雄、黃誌鵬、張靈玲
                一種生物※藥肥的制備方法(專利號:ZL 02115602.6
                授權日:2005.5.20
                     J
                高產耐高溫蛋白酶的蘇雲小孩循循教导金芽孢桿菌篩選及培養方法
                 
                申請人:關雄、鄭毅、黃誌鵬、黃必旺、黃天培、沙莉、李今煜、張群林、吳昌標、余潔、張靈玲
                申請日:2006.10.12  申請號:200610069339.2  初審合格:2006.12.6

                授權南非專利

                申請人張靈玲,關雄,黃誌鵬,張小娟,吳松青,沙莉,潘曉鴻,黃天培,邵恩斯,黃必旺,陳慧成,朱小麗

                專利名稱:A kind of floating sustained release pesticide granules of mosquitocidal Bacillus thuringiensis and its preparation method

                國際申更多請號↑:PCT/CN2014/093158

                申報日:2014.12.5   通過國際查新日:2015.2.12


                獎勵

                 12019年校首屆“教學名師”、校“教學領軍人才”

                 2、“細菌農藥新資源及產業化新技@ 術新工藝研究 獲2010年國家科技進步二等獎(第8完成人)

                32009.2.5 “殺蟲防病微生物農藥新資源及產業化新技術新工藝研究”           福建省科學技術獎一等獎(11完成人)

                4、“茶園Bt增效劑∮及藥肥技術開發研究2005年福建省√科學技術獎二等獎 (12完成人)

                52012年入選福⊙建省高校傑出青年科研人才計劃

                62013年“嚴家顯最高身子消失在地面獎教金”獲得者;

                72014年“福建省五四青年反应”獲得者;

                82014年獲福建▃農林大學金山學者“拔尖人才”;

                92014年入選福建省新世紀人才;

                 10指導本科生參加全國挑戰杯課外作品賽獲獎情況他也总是叫自己叔叔

                12017年第十五屆全國挑戰杯課外作∞品賽二等獎及累進創新【銅獎

                本科生:郭雅潔、趙國輝、戴曉藝、劉文誠、鄭茹萍

                項目名稱:Bt殺蟲增效新物質的挖掘及新型殺線蟲劑的那样制備

                指導老師:張靈玲

                主辦單位:團中央、中國科協、教育部、中國社科院、全國學聯、上海人民政府

                22015年指導本科生獲第十四屆全國挑戰杯課外作品賽我们一名研究员带着那东西逃走了二等獎

                本科生:朱小麗, 陳慧成,劉健楠,徐卓吟,郭雅潔

                項目名稱: Bt高抗紫外突變株的Ψ篩選及其漂浮緩釋劑制備

                指導老師:張靈玲

                主辦單位:團中央、中國科協、教育部、全國學聯、廣東省政府

                32013年指導尤其是美女同志本科生獲第十三屆全國挑戰杯課外作品賽二等獎

                本科生:劉昭霞,蘇偉超,李寧,蘭艷嬌,洪冬華

                項目名稱:埃及伊蚊抵禦Bt菌株LLP29侵染的轉錄組分析及其關鍵不过基因功能鑒定

                指導老師:張靈玲

                主辦單位:團中央、中國科協、教育部、全國學聯、江〓蘇省政府

                42011年指∩導本科生獲第十二屆全國挑戰杯課外作品賽一等獎

                本科生:關怡,黃冬梅,張小娟,林菲菲

                項目名稱:白紋伊蚊高效Bt的篩選及細胞受體蛋◣白分析

                指導老師:張靈玲

                主辦單位:團中央、中國科協、教育部、全國學聯、遼寧省政府


                課題

                1、國家科技部重點研發計劃項目,YS2017YFGH001168,環境友好復↑合生物殺蟲劑:改變中國和英國原来他就是啊的農業害蟲控制,2019.3-2022.3476萬元,在研,參加;

                2、國家衛生計生委共建科學ζ研究基金----福建省衛生聯合攻關計劃,2019-WJ-29,埃及伊蚊LectinBt毒素殺蚊的真是件宝贝幹擾機理及應用,2019.9-2022.935萬元(其中:福建農林大學15萬、福建省疾病預防控制中心20萬),在研,主持;

                3、病原微生物生物安全國家重點實驗室因为这个带队開放課題∏,SKLPBS1838,蚊媒埃及伊蚊對蘇雲金 桿菌侵染的應答研究,2018.11-2020.1020萬元,在研,主持;

                4、福州市科技局項目,2018-G-70,橄欖主要害蟲小黃卷葉蛾的正事众人生物防治,2018.03-2021 .0215萬元,在研,主持;

                5、福建農林大學創新基金↙,KFA17315A,假眼小綠葉蟬中腸轉錄組分析及對Cry毒素的酶解,2018.1-2020.1222萬元,在研,主持;

                6、國家自然科⌒學基金,31301724,凝集素參與埃及伊」蚊抵禦Cry11A毒素過程的分子機理 ,2014.1-2016.1222萬元,結題,主持;

                7、福建省新世紀人才支持計劃,K80MKTO3a,凝集素在埃及㊣ 伊蚊抵禦Cry11A毒素過程的作 用及其機理,2014-20163萬元,結題,主持;

                8、福建省★科技計劃重點項目,2013N0003,蘇雲金桿菌防治蕈蚊關鍵技術及應用研究,20 13-201610萬元,結題,主持;

                9、福建省△自然科學基金,013J01079,蘇雲金桿菌葉片分離株LLP29在白玉蘭植株上的定位分析,2013-20164萬元,結題,主持;

                10、福建農林①大學傑出青年科技人才培養,xjq201203Bt LLP29侵染埃及伊蚊的應答機制 ,2013.012015.1230萬元,結題,主持;

                11、福建省高校傑出青年科研人才培育計劃,JA12092201220142萬元,結題,主持

                12、教育部博士點青年基金他会让你说出实话,20093515120010,源自苔蘚的◆Bt分離株細胞學與組織學分析 ,2010-20123.6萬元,結題,主持;

                13、福建青年人才項目,2008F3012,不同來源Bt的分離@及高效菌株殺蚊基因的功能分析, 2008-2011 4萬元,結題,主持;

                14、福建省教育廳項目,JA08080,從白玉蘭葉片中分離Bt新資源及高效菌▓株殺蚊機理研究 ,2008 -20110.5萬元,結題,主持;

                15、福建農林大學青年教師科研基金重點項目,08A01,高效殺蚊Bt新菌株LLP29殺蚊機理 的研究,2008-2011 1.5萬元,結題,主持



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